Publications

Shepard, A., Hoxha, S., Troutman, S., Harbaugh, D., Kareta, M.S. and Kissil, J.L. “Transcriptional regulation of miR-30a by YAP imapcts PTPN13 and KLF9 levels and Schwann cell proliferation”. Journal of Biological Chemistry, In press, 2021.

Hoxha, S., Shepard, A., Troutman, S., Diao, H., Doherty, J.R., Janiszewska, M., Witwicki, R.M., Pipkin, M.E., Ja, W.W., Kareta, M.S. and Kissil, J.L. “YAP-mediated recruitment of YY1 and EZH2 represses transcription of key cell cycle regulators”. Cancer Research, 80:2512-2522, 2020.

Shepard, A. and Kissil, J.L. “The use of non-traditional models to understand cancer resistance – The case of the Naked Mole Rat”. Oncogene, 39:5083-5097, 2020.

Carper, M.B., Selitsky, S.R., Troutman, S., Wagner, B., Byrd, K.M., Sharma,K.P., Henry, E.C., Li, W., Parker, J., Montgomery, S.A., Cleveland, J.L., Williams, S.E., Kissil, J.L., Hayes, D.N. and Amelio, A.L. “An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma”. Cell reports, 29;1660-1674, 2019.

Cui, Y., Groth, S., Carlstedt, A., Sperka, T., Riecken, L.B., Troutman, S., Kissil, J.L., Jin, H. and Morrison, H. “The NF2 tumor suppressor merlin interacts with RasGAP to negatively regulate Ras” Oncogene 38;6370-6381, 2019

Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J.L.# and Spicer, T.P.# (#corresponding authors). “A novel 3-dimenasional high throughput screening approach identifies inducers of a KRAS selective lethal phenotype”. Oncogene 37;4372-4384, 2018.

Chinthalapudi, K., Mandati, V., Zheng, J., Griffin, P., Kissil, J.L., and Izard, T. “Lipid binding promotes the open conformation, membrane localization and tumor-suppressive activity of neurofibromin 2”. Nature Communications, 9(1338), 2018

Moleirinho, S., Hoxha, S., Mandati, V., Curtale, G., Troutmen, S., Ehmer, U. and Kissil, J.L. “Regulation of localization and function of the transcriptional co-activator YAP by angiomotin”. eLIFE. 2017, 6e23966.

Troutman, S., Moleirinho, S., Kota, S., Nettles, K., Fallahi, M., Johnson, G.L. and Kissil, J.L. “Crizotinib inhibits NF2-associated schwannoma through inhibition of Focal Adhesion Kinase 1”. Oncotarget. 7(34):54515-25, 2016.

Guerrant, W., Kota, S., Troutman, S., Mandati, V., Fallahi, M., Stemmer-Rachamimov, A. and Kissil, J.L. “YAP mediates tumorigenesis in neurofibromatosis type 2 by promoting cell survival through a COX2-EGFR signaling axis”. Cancer Research. 76(12):3507-19, 2016

Yi, C., Shen, Z., Stemmer-Rachamimov, A., Dawany, N., Troutman, S., Showe, L.C., Liu, Q., Shimono, A., Sudol, M., Holmgren, L., Stanger, B.Z. and Kissil, J.L. “Angiomotin-p130 is required for Yap-mediated hepatic epithelial cell expansion and tumorigenesis”. Science Signaling. 6:ra77, 2013.

Licciulli, S., Maximoska, J., Zhou, C., Troutman, S., Kota, S., Liu, Q., Duron, S., Campbell, D., Chernoff, J., Field, J., Marmorstein, R. and Kissil, J.L. “FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of NF2-associated schwannomas”. J Biol Chem. 288(40):29105-14, 2013.

Licciulli, S., Avila, J.L., Hanlon, L., Troutman, S., Cesaroni, M., Keith, B., Simon, M.C., Pure, E., Radtke, F., Capobianco, A.J. and Kissil, J.L. “Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cells survival via p53”. Cancer Research. 73(19):5974-84, 2013.

Yi, C., Troutman, S., Fera, D., Stemmer-Rachamimov, A., Avila, J., Christian, N., Persson, N.L., Speicher, D.W., Shimono, A., Marmorstein, R., Holmgren, L. and Kissil, J.L. “A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin’s Regulation of Mitogenic Signaling and Tumor Suppressive Functions”. Cancer Cell. 19:527-540, 2011

Link to more of our work on PubMed